x1 = EGFR_active x2 = D_SOS x3 = A_SOS x4 = Raf x5 = Ras_active x6 = Mek_active x7 = ERK x8 = ERK_active x9 = IGFR_active x10 = PI3KCA x11 = PI3KCA_active x12 = AKT_active x13 = AKT x14 = PP2A x15 = Ras x16 = Raf_active x17 = Mek x18 = RasGapActive x19 = RafPP x20 = P90RskInactive x21 = P90Rsk_Active