TGFb -> 0 TGFb_R2_surface -> 0 0 -> Active_R2 Active_R2 -> 0 0 -> TGFb_R2_surface 0 -> TGFb Active_R2 + TGFb_R1_surface -> Active_Rec Active_Rec -> Active_R2 + TGFb_R1_surface Active_Rec_endo -> TGFb_In + TGFb_R1_endo Active_Rec_endo -> TGFb_In + TGFb_R2_endo Active_Rec_endo -> TGFb_R1_endo + TGFb_R2_endo TGFb_R1_endo -> 0 TGFb_R2_endo -> 0 Active_Rec + S7 -> Inactive_Rec Inactive_Rec -> Active_Rec + S7 Inactive_Rec -> S7 + TGFb_R1_surface + TGFb_R2_surface Inactive_Rec -> S7 + TGFb_In + TGFb_R1_surface TGFb_R1_surface -> TGFb_R1_endo TGFb_R2_surface -> TGFb_R2_endo TGFb_R1_endo -> TGFb_R1_surface TGFb_R2_endo -> TGFb_R2_surface Active_Rec -> Active_Rec_endo Active_Rec_endo -> TGFb_In + TGFb_R1_endo + TGFb_R2_endo TGFb_In -> 0 S2_c -> pS2_c S4_c + 2*pS2_c -> pS2_pS2_S4_c pS2_pS2_S4_c -> S4_c + 2*pS2_c S4_n + 2*pS2_n -> pS2_pS2_S4_n pS2_pS2_S4_n -> S4_n + 2*pS2_n 3*pS2_c -> pS2_pS2_pS2_c 3*pS2_n -> pS2_pS2_pS2_n pS2_pS2_pS2_n -> 3*pS2_n pS2_pS2_pS2_c -> 3*pS2_c S2_c -> S2_n S2_n -> S2_c S4_c -> S4_n S4_n -> S4_c pS2_c -> pS2_n pS2_n -> pS2_c pS2_pS2_S4_c -> pS2_pS2_S4_n pS2_pS2_pS2_c -> pS2_pS2_pS2_n pS2_n -> S2_n pS2_pS2_S4_n -> S2_n + S4_n + pS2_n 0 -> S2_c 0 -> S4_c 0 -> TGFb_R1_surface 0 -> TGFb_R2_surface 0 -> Smad7mRNA1 Smad7mRNA1 -> Smad7mRNA 0 -> S7 S2_c -> 0 S2_n -> 0 pS2_n -> 0 pS2_c -> 0 S4_c -> 0 S4_n -> 0 pS2_pS2_S4_c -> S4_c + pS2_c pS2_pS2_S4_c -> 2*pS2_c pS2_pS2_pS2_c -> 2*pS2_c pS2_pS2_S4_n -> S4_n + pS2_n pS2_pS2_S4_n -> 2*pS2_n pS2_pS2_pS2_n -> 2*pS2_n Smad7mRNA1 -> 0 Smad7mRNA -> 0 S7 -> 0