0 -> cyclin_D_Cdk4_6 cyclin_D_Cdk4_6 -> 0 0 -> transcription_factor_E2F_active transcription_factor_E2F_active -> 0 0 -> cyclin_E_Cdk2 cyclin_E_Cdk2 -> 0 0 -> cyclin_A_Cdk2 cyclin_A_Cdk2 -> 0 0 -> cyclin_B_Cdk1 cyclin_B_Cdk1 -> 0 0 -> Cdc20_active Cdc20_active -> 0