0 -> Cyclin_D
Cyclin_D -> 0
Cdk4 + Cyclin_D -> Cyclin_D_Cdk4
Cyclin_D_Cdk4 -> Cdk4 + Cyclin_D
0 -> Cyclin_E
Cyclin_E -> 0
Cdk2 + Cyclin_E -> Cyclin_E_Cdk2_inactive_phosphorylated
Cyclin_E_Cdk2_inactive_phosphorylated -> Cdk2 + Cyclin_E
0 -> Cyclin_A
Cyclin_A -> 0
Cdk2 + Cyclin_A -> Cyclin_A_Cdk2_inactive
Cyclin_A_Cdk2_inactive -> Cdk2 + Cyclin_A
Cyclin_D_Cdk4 -> Cdk4
Cyclin_A_Cdk2_active -> Cdk2
Cyclin_A_Cdk2_inactive -> Cdk2
Cyclin_E_Cdk2_inactive_phosphorylated -> Cdk2
Cyclin_E_Cdk2_active_unphosphorylated -> Cdk2
Cyclin_D_Cdk4 + p21 -> p21_CyclinD_Cdk4
p21_CyclinD_Cdk4 -> Cyclin_D_Cdk4 + p21
Cyclin_D_Cdk4 + p27 -> p27_CyclinD_Cdk4
p27_CyclinD_Cdk4 -> Cyclin_D_Cdk4 + p27
Cyclin_E_Cdk2_inactive_phosphorylated -> Cyclin_E_Cdk2_active_unphosphorylated
Cyclin_E_Cdk2_active_unphosphorylated -> Cyclin_E_Cdk2_inactive_phosphorylated
Cyclin_E_Cdk2_active_unphosphorylated + p27 -> p27_CyclinE_Cdk2
p27_CyclinE_Cdk2 -> Cyclin_E_Cdk2_active_unphosphorylated + p27
Cyclin_E_Cdk2_active_unphosphorylated + p21 -> p21_CyclinE_Cdk2
p21_CyclinE_Cdk2 -> Cyclin_E_Cdk2_active_unphosphorylated + p21
Cyclin_A_Cdk2_inactive -> Cyclin_A_Cdk2_active
Cyclin_A_Cdk2_active -> Cyclin_A_Cdk2_inactive
Cyclin_A_Cdk2_active + p27 -> p27_CyclinA_Cdk2
p27_CyclinA_Cdk2 -> Cyclin_A_Cdk2_active + p27
Cyclin_A_Cdk2_active + p21 -> p21_CyclinA_Cdk2
p21_CyclinA_Cdk2 -> Cyclin_A_Cdk2_active + p21
0 -> p27
p27 -> 0
p27 -> 0
0 -> p21
0 -> p21
p21 -> 0
0 -> p16
0 -> p16
p16 -> 0
Cyclin_D_Cdk4 + p16 -> 0
E2F + Rb -> Rb_E2F
Rb_E2F -> Rb_PP_E2F
Rb_E2F -> Rb_PP_E2F
Rb_E2F -> Rb_PP_E2F
Rb_PP_E2F -> E2F + Rb_PPP
Rb_PP_E2F -> E2F + Rb_PPP
0 -> E2F
0 -> E2F
E2F -> 0
E2F -> 0
Rb_PPP -> Rb
0 -> Rb
Rb -> 0
0 -> Rb
0 -> p53
0 -> p53
p53 -> 0
0 -> Mdm2
Mdm2 -> 0
0 -> Mdm2
Intermediate -> 0
0 -> Intermediate
0 -> Cyclin_A
0 -> ATM_ATR
ATM_ATR -> 0
0 -> Cdc25A_inactive
Cdc25A_inactive -> 0
Cdc25A_inactive -> Cdc25A_active
Cdc25A_inactive -> 0
Cdc25A_active -> 0
Cdc25A_active -> Cdc25A_inactive
Cdc25A_active -> 0
Chk1_active -> Chk1_inactive
Chk1_inactive -> Chk1_active
0 -> NF_Y
NF_Y -> 0
0 -> Cyclin_B
Cyclin_B -> 0
Cdk1 + Cyclin_B -> Cyclin_B_Cdk1_inactive_unphosphorylated_cytoplasm
Cyclin_B_Cdk1_inactive_unphosphorylated_cytoplasm -> Cdk1 + Cyclin_B
Cyclin_B_Cdk1_inactive_unphosphorylated_cytoplasm -> Cyclin_B_Cdk1_active_phosphorylated_cytoplasm
Cyclin_B_Cdk1_active_phosphorylated_cytoplasm -> Cyclin_B_Cdk1_inactive_unphosphorylated_cytoplasm
Cyclin_B_Cdk1_inactive_unphosphorylated_cytoplasm -> Cdk1
Cyclin_B_Cdk1_active_phosphorylated_cytoplasm -> Cdk1
0 -> Wee1
Wee1 -> Wee1_phosphorylated
Wee1_phosphorylated -> Wee1
Wee1_phosphorylated -> 0
Cyclin_B_Cdk1_nuclear + p21 -> p21_CyclinB_Cdk1
p21_CyclinB_Cdk1 -> Cyclin_B_Cdk1_nuclear + p21
0 -> B_Myb_inactive
B_Myb_inactive -> B_Myb_active
B_Myb_active -> 0
0 -> Cdc25C_inactive
Cdc25C_active -> Cdc25C_inactive
Cdc25C_inactive -> Cdc25C_active
Cdc25C_inactive -> Cdc25C_Ps216_phosphorylated_inactive
Cdc25C_Ps216_phosphorylated_active -> Cdc25C_active
Cdc25C_active -> Cdc25C_Ps216_phosphorylated_active
Cdc25C_active -> 0
Cdc25C_Ps216_phosphorylated_active -> Cdc25C_Ps216_phosphorylated_inactive
Cdc25C_Ps216_phosphorylated_inactive -> Cdc25C_Ps216_phosphorylated_active
0 -> _14_3_3_sigma
0 -> _14_3_3_sigma
_14_3_3_sigma -> 0
Cdc25C_Ps216_phosphorylated_inactive + _14_3_3_sigma -> _14_3_3_sigma_iCdc25C_PS216_phosphorylated
_14_3_3_sigma_iCdc25C_PS216_phosphorylated -> 0
APC_Ccdc20_active -> APC_Ccdc20_inactive
APC_Ccdc20_inactive -> APC_Ccdc20_active
APC_Ccdh1_active -> APC_Ccdh1_inactive
APC_Ccdh1_inactive -> APC_Ccdh1_active
Cyclin_A -> 0
Cyclin_A -> 0
Cyclin_B -> 0
Cyclin_B -> 0
0 -> Cyclin_A
Cyclin_B_Cdk1_active_phosphorylated_cytoplasm -> Cyclin_B_Cdk1_nuclear
Cyclin_B_Cdk1_nuclear -> Cyclin_B_Cdk1_active_phosphorylated_cytoplasm
Cyclin_B_Cdk1_nuclear -> Cyclin_B_Cdk1_nuclear_inactive
Cyclin_B_Cdk1_nuclear_inactive -> Cyclin_B_Cdk1_nuclear
Cyclin_B_Cdk1_nuclear -> 0
Cyclin_B_Cdk1_nuclear_inactive -> 0
Cyclin_B_Cdk1_nuclear -> 0
p53 -> 0