IR -> pIR pIR -> IR IRS -> pIRS pIRS -> IRS Akt -> pAkt pAkt -> Akt mTORC1 -> pmTORC1 pmTORC1 -> mTORC1 mTORC2 -> pmTORC2 pmTORC2 -> mTORC2 DEPTOR -> pDEPTOR pDEPTOR -> DEPTOR DEPTOR + mTORC1 -> mTORC1_DEPTOR mTORC1_DEPTOR -> DEPTOR + mTORC1 DEPTOR + mTORC2 -> mTORC2_DEPTOR mTORC2_DEPTOR -> DEPTOR + mTORC2 IRS -> iIRS iIRS -> IRS 0 -> DEPTOR pDEPTOR -> 0