IR -> pIR pIR -> IR IRS -> pIRS pIRS -> IRS Akt -> pAkt pAkt -> Akt mTORC1 -> pmTORC1 pmTORC1 -> mTORC1 mTORC2 -> pmTORC2 pmTORC2 -> mTORC2 DEPTOR -> pDEPTOR pDEPTOR -> DEPTOR DEPTOR + mTORC1 <-> mTORC1_DEPTOR DEPTOR + mTORC2 <-> mTORC2_DEPTOR IRS -> iIRS iIRS -> IRS 0 -> DEPTOR pDEPTOR -> 0