pEGFR <-> fEGFR RafPPtase + pRaf1 <-> Raf1 + RafPPtase pAkt + pRaf1 <-> Raf1 + pAkt MEK + pBRaf <-> pBRaf + pMEK MEK + pRKIP + pRaf1 <-> pMEK + pRKIP + pRaf1 PP2A + pMEK <-> MEK + PP2A ERK + pMEK <-> pERK + pMEK PP2A + pERK <-> ERK + PP2A RKIP + pERK <-> pERK + pRKIP pRKIP <-> RKIP RKIP <-> null BRaf + pRas <-> pBRaf + pRas BRaf + pRap1 <-> pBRaf + pRap1 pP90Rsk <-> P90Rsk P90Rsk + pERK <-> pERK + pP90Rsk PI3K + bEGFR <-> bEGFR + pPI3K PI3K <-> pPI3K pPI3K <-> PI3K EGF + fEGFR <-> bEGFR PIP2 + pPI3K <-> PIP3 + pPI3K PIP3 + PTEN <-> PIP2 + PTEN Akt + PIP3 <-> PIP3 + pAkt pAkt <-> Akt C3G + bEGFR <-> bEGFR + pC3G pC3G <-> C3G Rap1 + pC3G <-> pC3G + pRap1 Rap1Gap + pRap1 <-> Rap1 + Rap1Gap GSK3B <-> GSK3B + PKCD PKCD <-> null GSK3B + pERK <-> pERK + pGSK3B GSK3B + pAkt <-> pAkt + pGSK3B RKIP <-> GSK3B + RKIP pGSK3B <-> GSK3B Dshi <-> Dsha Dsha <-> Dshi APCAxinGSK3B + Dsha <-> APCAxin + Dsha + GSK3B APCAxin + GSK3B <-> APCAxinGSK3B APCAxinGSK3B <-> pAPCpAxinGSK3B pAPCpAxinGSK3B <-> APCAxinGSK3B APC + Axin <-> APCAxin Axin <-> null BCatenin + TCFBCatenin <-> Axin + BCatenin + TCFBCatenin BCatenin + pAPCpAxinGSK3B <-> pAPCpAxinGSK3BBCatenin pAPCpAxinGSK3BBCatenin <-> pAPCpAxinGSK3BpBCatenin pAPCpAxinGSK3BpBCatenin <-> pAPCpAxinGSK3B + pBCatenin APC + BCatenin <-> APCBCatenin null <-> BCatenin BCatenin <-> null BCatenin + TCF <-> TCFBCatenin TCFBCatenin <-> TCFBCatenin + X X <-> null pBCatenin <-> null PKCD + SOS + bEGFR + pERK <-> PKCD + bEGFR + pERK + pSOS pSOS <-> SOS pP90Rsk + pSOS <-> SOS + pP90Rsk Ras + pSOS <-> pRas + pSOS null <-> Ras RasGap + pRas <-> Ras + RasGap Raf1 + pRas <-> pRaf1 + pRas Raf1 + X <-> X + pRaf1 RafPPtase + pBRaf <-> BRaf + RafPPtase pAkt + pBRaf <-> BRaf + pAkt