k1 = a k2 = c k3 = aa k4 = g2 k5 = u2 k6 = p1 k7 = g1 k8 = p2 k9 = g3 k10 = u3 k11 = alpha k12 = g4 k13 = gamma k14 = u1 k15 = p3 k16 = p4 k17 = q1 k18 = q2 k19 = theta k20 = k k21 = tumor_microenvironment